The New York Empire Express inspired the engraving for the 2-cent stamp of the Pan American Issue. The engine was a logical choice since the Exposition was taking place in New York State and the train was one of the era's most modern. The carmine and black stamp was the first 2-cent denomination printed in more than one color. Another multicolored 2-cent stamp did not appear until the 2-cent Sloop from the Norse-American Issue of 1925. It should also be noted that the 2-cent denomination saw the greatest use of the entire Pan American Issue.
The Pan American Issue's six stamps were the first multicolored stamps since the 1869 Pictorial Issue. Like that issue, the first three denominations of the Pan American produced inverts.
This 2-cent stamp typically paid the first-class domestic rate. In combination with other denominations, it fulfilled large weight and foreign destination rates. It is probably one of the most recognizable twentieth century US stamps. It was printed in great quantities and is, therefore, very affordable for beginning stamp collectors. The Bureau of Engraving and Printing produced 209,759,700 of these stamps.